화학반응의 여러 데이타 3 == uuii.txt

화학반응의 여러 데이타 3 == uuii.txt

화면을 올바르게 보기위해서는 에디터나 , 워드 프로세서의 글꼴을 다음과 같이 세팅해야 함

글꼴 -- Lucida console

courier new

로 세팅해야 함

아래의 html 문서도 Lucida console , courier new 의 글꼴로 해서 봐야 하나

그냥 올리니 보고싶은 사람은 다운로드 해서 에디터나 , 워드 프로세서로 볼것

아래의 데이터의 작성된 시기 ---- 1997 년 --- 1998

download file

1139559168_UUII.txt

UUII.txt

------------------------------------------------------------------------------------------------

---------- this text written by choi myung hoan .1997 - 1998
---------- 지은이 : 최명환 .1997 - 1998

─ │ ┌ ┐ ┘ └ ├ ┤ ┴ ┬ ┼
─ │ ┌ ┐ ┘ └ ├ ┤ ┴ ┬ ┼

[!neuron__] !vervindungsformeln
[!muscle__] !error
[!ion carrier]
----------------
----[!prosthetic group].start ---
[prosthetic group]=[bogyeolueonjadan]
[!tpp]
[thf]=[tetrahydrofolate] ;stryer.611,garret.523
=[polsan];[metyl donor]
[tetrahydrobiopterin]
[tpp]=[thiamine pyrophosphate]
;st.383,402,460
[plp]=[pyridoxal phosphate]=[piridogsalinsan]
;[nh.donor];st.524,garret.505,[vitamin b6]
[retinal__]
[engery compound]
[!covalent_intermediate_enz.].start
--[retinal__].start-------
--[retinal.make.rodopsin].start---
;stryer.1083,garret.528
j10-->
[vitamin a]=[retinol]
[xxxase]
2┬2(ch3) ┌ch3 ┌ch3
ch2──c1──c─ch┬ch─c┬ch─ch┬ch─c┬ch─ch2oh
│ 2┤ 2 2 2 2 │ │
ch2──ch2─c─ch3 nad(u+)<<───┴─<┘

j11-->
[retinal.trans.380nm]
[xxxase]=[retinal isomerase]
2┬2(ch3) ┌ch3 ┌h ┌ch3
ch2──c1──c─ch┬ch─c┬ch─c11┬c──c┬ch─cho
│ 2┤ 2 2 2└h 2
ch2──ch2─c─ch3 nadh+h(u+)

j12-->
[retinal.(cis.11).500nm]
; 40*10^4 cm^-1*M^-1
[xxxase]
2┬2(ch3) ┌ch3 ┌h 2┌h
ch2──c1──c─ch┬ch─c┬ch─c11h┴c──┐ h
│ 2┤ 2 2 h3c───c─┘ │2
ch2──ch2─c─ch3 ┌─>>──┐2┴ch─c┴o
┌──────────┬─lys─nh3(u+)└─────┼─┘
└─[opsin]──┘ └──────>─────┘

j13-->
[rodopsin]
[xxxase]
2┬2(ch3) ┌ch3 2
ch2──c1──c─ch┬ch─c┬ch─c11h┴ch─┐ h
│ 2┤ 2 2 h3c───c─┘ │
ch2──ch2─c─ch3 2┴ch─c h2o
┌──────────┬─lys─nh(u+)───2───┘
└─[opsin]──┘
--[retinal.make.rodopsin].end---

--[bagteriorodopsin].start---
r1=[retinal]
2┬2(ch3) ┌ch3 ┌ch3
ch2──c1──c─ch┬ch─c┬ch─ch┬ch─c┬ch─ch─2─
│ 2┤ 2 2 2 2
ch2──ch2─c─ch3

;stryer.1014
j10-->
a1=[bagteriorodopsin]=25kd
[r1.570nm].trans
┌──a1──────┐
r1─2─nh(u+)─lys.───────┘
└──<<────[licht]
j10_5-->
[r1.610nm].cis.13 , 10ps.
┌──────>h(u+)
│ ┌──a1──────┐
r1─2─nh(u+)─lys.───────┘

j11-->
[r1.412nm].cis.13 , 40micro.s.
h(u+) ┌──a1──────┐
r1─2─n──────lys.───────┘
└──<───h(u+)
j12-->
[r1.570nm].trans , 4 ms.
┌──a1──────┐
r1─2─nh(u+)─lys.───────┘

--[bagteriorodopsin].end---

--[retinal__].end-------
--[engery compound].start---
garret.551
g=xx kj/mol
┌[guadinyum]
│ └──-[insancreatin.make]
└[!ester]
[!atp_need]

----[o2.eng.].start---
g=-220 kj/mol
(1/2)o2+ nadh+h(u+) -->h2o + nad(u+)
----[o2.eng.].end---
----[pep.start]---
[pep]=[phosphoenolpyruvate]
g=-62.2 kj/mol
2┌pi
ch2┴─c─coo(u-)
pr1.
[pep]
g=-28.6 kj/mol
┌─<<─hoh
2 ┌pi
ch2┴─c─coo(u-)

pr2.
[xxx]
g=-33.6 kj/mol
┌──────┐
│ 2 ┌oh pi
ch2┴─c─coo(u-)
pr3.
[pyruvate]
2┬o
ch3─c─coo(u-)
----[pep.end]---
;----
----[camp.eng.].start---
camp=[adenosin il insan]--> amp
g=-50.4 kj/mol
┌──ribose──┬─adenin ┌──ribose──┬─adenin
└─5'────3'┬┘ ===> └─5'────3'─┘
└──pi─┘ └2'─oh └pi ho┘
----[camp.eng.].end---

----[bpg.eng.].start---
[1,3bisphosphoglycerate]=[bpg]
g=-49.6 kj/mol
pr1.
ch2opo3(u2-)
│ hoh
hcoh┌──<─┘││
2│ │┌─<<─┴┘
o┴c─o─po3(u2-)
[3phosphoglycerate]=[3pg]
pr2.
ch2opo3(u2-)
│ hoh
hcoh┌──<─┘││
2│ │┌─<<─┴┘
o┴c─o─h pi
----[bpg.eng.].end---

-----[guadinyum].start---
garret.560
2┬nh2(u2+)
│ ┌──────<─────┐
r─c─nh─po3(u2-) hoh
└──────────┴┘
----[insancreatin].start----
[insancreatin]=[creatine phosphate]
g=-43.3 kj/mol
pr1.
2┬nh2(u2+)
│ ┌──────<─────┐
┌─c─nh─po3(u2-) hoh
│ └──────────┴┘
ch3─n─ch2─coo(u-)
pr2.
2┬nh2(u2+)
┌─c─nh2 pi
ch3─n─ch2─coo(u-)
----[insancreatin].end----
----[insancreatin.make].start----
pr1.
┌────<────┐
│┌───<<──┐│
atp ┌─nh2
┌─c─2─nh2(u2+)
ch3─n─ch2─coo(u-)
pr2.
adp ┌─nh─po3(u2-)
┌─c─2─nh2(u2+)
ch3─n─ch2─coo(u-)
----[insancreatin.make].end----
----[insan─arg.].start----
[insan─arg.]
g=-43.3 kj/mol
┌─<<──hoh
arg.─nh─po3(u2-)
----[insan─arg.].end----
-----[guadinyum].end---

----[insancacetyl].start----
[insancacetyl]
g=-43.3 kj/mol

ch3─co─pi ==> ch3─cooh pi
----[insancacetyl].end------
----[atp].start----
pk4.pppi.atp=6.95 ;garret.566
pk1.nh3.atp=4.06
pr1.
[atp]
g=-35.7 kj/mol
o┬2 o┬2 o┬2
r─o─p─o────p─o─────p─oh
└o[u-] └o[u-] │└o[u-]
┌─>>──┘ │
│┌┬────>>───┘
hoh
pr2.
adp phosphation
o┬2 o┬2 o┬2
r─o─p─o────p─o───h + ho─p─oh
└o[u-] └o[u-] └o[u-]

[atp]+mg(u2+)-->[adp]+pi
g=-30.5 kj/mol
[atp]+mg(u2+)-->[amp]+ppi
g=-32.5 kj/mol
----[atp].end----
----[adp].start----
[adp]-->[amp]+pi
g=-35.7 kj/mol
----[adp].end----
----[amp].start----
[amp]-->[adenosin]+pi
g=-9.2 kj/mol
----[amp].end----
----[ppi].start--
pk1=0.8
pk2=2.0
pk3=6.7
pk4=9.4
┌o(u-) ┌o(u-)
o─2─p───o───p─2─o
└o[u-] └o[u-]

[ppi]+mg(u2+).5mM.-->pi+pi
g=-33.6 kj/mol
----[ppi].end--
----[acetyl─coa.start]---
[acetyl─coa]
g=-31.5 kj/mol
┌──<<─hoh
ch3─co─s─coa ==> ch3─cooh + hs─coa
----[acetyl─coa.end]---
----[glucose.udp.start]---
[glucose.udp]
g=-31.9 kj/mol
pr1.
┌ch2oh
┌─ch─o─┐ ┌─<<──hoh
hoch┌oh ch─[udp.]
└─ch─ch┘
└oh
pr2.
┌ch2oh
┌─ch─o─┐
hoch┌oh choh udp
└─ch─ch┘
└oh
----[glucose.udp.end]---
----[met.adenosin.start]---
[met.ribose.adenin.]
g=-25.6 kj/mol
pr1.
┌ch2─met.
h3c─s(u+)
┌──┘<<────hoh
┌─5'ch2────┬─adenin
└─ribose───┘
pr2.
[met.]+[ribose.adenin.]
┌ch2─met.
h3c─s h(u+)
┌oh
┌─5'ch2────┬─adenin
└─ribose───┘
----[met.adenosin.end]---
----[glucose.pi.start]---
[glucose-1.pi]=[glucosil insan]
g=-21.0 kj/mol
pr1.
┌ch2oh
┌─ch─o─┐ ┌─<<──hoh
hoch┌oh ch─pi
└─ch─ch┘
└oh
pr2.
┌ch2oh
┌─ch─o─┐
hoch┌oh choh pi
└─ch─ch┘
└oh
[glucose-6.pi]=[glucos-6-insan]
g=-13.9 kj/mol
pr1.
┌ch2───pi
┌─ch─o─┐ └─<<──hoh
hoch┌oh choh
└─ch─ch┘
└oh
pr2.
┌ch2oh pi
┌─ch─o─┐
hoch┌oh choh
└─ch─ch┘
└oh
----[glucose.pi.end]---
----[fructose-6-phosphate.start]-----
[fructose-1-phosphate]
g=-16.0 kj/mol
┌ch2oh
┌─ch─o ┌<<─hoh
hoch┌oh│ ch2─pi
└─ch─c─┘
└oh
----[fructose-6-phosphate.start]-----
----[glycerol-3-phosphate.start]
[glycerol-3-phosphate]
g=-9.2 kj/mol
┌─ch2───pi
ch───oh └─<<─hoh
└─ch2oh
----[glycerol-3-phosphate.end]

----[!ester].start----
g=-35.7 kj/mol
2┬o┌──<<──hoh
r1─c─c──o─po3─c─r2
g=-35.7 kj/mol
2┬o┌──<<──hoh
r1─ch─c──o─c─r2
g=-31.7 kj/mol
2┬o┌──<<──hoh
r1─c──c──s─c─r2
----[!ester].end----
----[!atp_need].start----
;garret.568
11700kj=2800kcal=5850kj.atp.50%=70kg.man
1.atp/mol=50kj , 5850kj/50kj=117.atp/mol
551g=1.atp/mol
117/mol * 551g/mol=64467g.atp/1.day
70kg.man=65kg.atp=50g.atp * 1300
----[!atp_need].end----
!error
[ring.c│n].go.1360
[ring.c│c].go.4255
[ring.c│c].go.2847
[indol-3-glyserol-pi].error
--[!covalent_intermediate_enz.].start--
;garret.456
ser.─oh --> ser.─o───co─r
[kimotripsin],[elastin gasubunhai]
[ester gasubunhai][subtilisin]
[trombin][tribsin]

cys.─sh --> cys.─s───co─r
[glyseraldehidsaminsantalsuso]
[papain]

ser.─oh --> ser.─pi
[pospoglucojariomgim]

his.─nh─ --> his.─n─
└─po3(u2-)
[pospoglisersanjariomgim]
[succinyl─coa]

lys.─nh3(u+) --> lys.─n─2─c─2─
[aldolgasubunhai][talcarboxy]
[piridogsal]
--[!covalent_intermediate_enz.].end--

--[!tpp].start--

[tpp]=[thiamine pyrophosphate]
;st.383,402,460
---[tpp.make].start--
j50-->
[vitamin-b1]=[thiamine]
[xxxase]
h┐ ┌──<──┐
2┌nh2 2┬─c──s │┌─<<┐│
n┴c─c─ch2─n(u+)│ atp ││
│2 ├2 └─c┬─c─2(ch2)─oh
c┴n─c─h h3c┘2
└─ch3
j51-->
[tpp]
[xxxase]
h┐
2┌nh2 2┬─c──s
n┴c─c─ch2─n(u+)│ amp
│2 ├2 └─c┬─c─2(ch2)─ppi
c┴n─c─h h3c┘2
└─ch3
---[tpp.make].end--
----[ksilulos 5-phosphate.make].start-----
[ribose 5-phosphate]
[phosphopentose epimerase]
┌ch2opo3(u2-)
│ ┌>─┐
│ │┌─┼─────┐
┌ch┼o─ch─oh │
│┌hh┐<┼──<──┘
└c──c─┘
ho┘ └oh
[ksilulos 5-phosphate]
┌ch2opo3(u2-)
│
┌ch─o ch2─oh
│┌h │ │
└c──c─┘
ho┘ └oh
----[ksilulos 5-phosphate.make].end-----

----[!prosthetic group].start ---
!vervindungsformeln
!san
!seramig
!sanso

!san
!tansan=h2co3
2┬o
h─o─c─o─h
!jilsan=hno3
2┬o
o─2─n─o─h
!hoangsan=h2so4
2┬o
h─o─n─o─h
2┴o
!hClo
h─o─cl

!seramig
g/cm^3 gpa
sanhoamul [mp] [mildo] [tanseong] [mohs]
alumina, al2o3 2072 4.0 380 9
brilia , beo 2530 3.0 370 8
jirconia,Zro2 2700 5.9 210 8

bisanhoamul
tanhoabungso,b4c 2350 2.5 280 9
tanhoagyuso ,Sic 2700 3.2 400 9
jilhoagyuso ,si3n4 1900 3.4 310 9

metal
aluminium 660 2.7 70 3
tansogang 1515 7.9 210 5

!sanso ;hgc.204
(0.0342).o2.gas/h2o.aq.volumen
;hgc.233
(1.713).co2.gas/h2o.aq.volumen

[!ion carrier]
;stryer.1019
[balinomasin]─6(val.─2─o)..k(u+) > 1000*na(u+)*eng.
[nonagtin]─6(o)...k(u+)
k(u+) =low.(u-)─pro.
Na(u+)=high.(u-).[small.r]─pro.
[suhoa energy]
no.,ion[=r=ongs.],kcal/mol=[suhoa energy]
Li(u+) 3 0.60 -98
Na(u+) 11 0.95 -72
k(u+) 19 1.33 -55
Rb(u+) 37 1.48 -51
Cs(u+) 55 1.69 -47

--[!neuron__].start---
!neuron.speed
[!jungchuSinGyeongGyeoi]
[!axonal transport]
[a1]=[cell body]=[soma],a3=[dendrite]
[a2]=[schwann cell],a7=[telodendria]
[a5]=[!axon]=[chugsag],a9=[eng.]
[a11]=[node of ranvier]=2mm.abstand.
[a710]=[!synapse]=a7<->a3
[a12]=[axon hillock]

┌<┬─<<──a7.a5.a1.a5.a3<<───[eng.]
┐<┘ ┌a13
└┐ ┌─a1─┐ ├┐ ┌─┬a14 a7
a3─┴┬┘ │ ┌a2┐┌──┐ ┌──┐ ┌┬┘
┬─┤─>┐ └──┴──┴┴──┴─┴──┴───┼─ ┌a7
└┐ └─a9────>──a9──>>───> │ │
│a12=┬─┐│<--- a5 ---->│ │ │
│ ┌──┬──┬┬──┬─┬──┬───┴┬─┴
│ │ └──┘└──┘ └──┘ ┴┬─
└─┬──┘ └┬┘ a7
a3─┴─a3──┴─ └─=[a11]


+40mv ┌┐ ┌┐
│ ││ ││
├────────────────────────┼┼───┼┼
│ ┌─┐ ┌─┐ ││ ││
│ │ └┐ │ └┐ ││ ││
│ │ └┐ │ └┐ ││ ││
-70mv─┘ └──┐ ┌──┘ └───┘└───┘└
│ │ ┌┘
│ └─┘

[epsp] [ipsp][a12] [a13] [a14]
[epsp]=excitory postsynaptic potential
[ipsp]=unterdruicken postsynaptic potential

-----[!synapse].start-------
a7=[telodendria]=[chemische synapse]
=[presynaptic membrane]
a3=[dendrite]=[presynaptic membrane]
a70=[singyeongjeondalmuljil]=[acetylcholin]
a71=[300]*[10^4]*[a70]
a700=[=r=50nm]=10^4<->5*10^4
a710=[synapse]
[a702]=[cholin]=ho─ch2─ch2─n(u+)─3─(ch3)3
[a701]=[h3c─coo(u-)]+[a702]
[a703]=[acetylcholinester gasubunhai].protein.=260kd
=12000.[micro.m]^-2 ;stryer.1078
a72=[nicoticnic acetylcholine receptor]
=268kd=50*5kd
=6000.[micro.m]^-2 ;stryer.1078
┌─<──ca(u2+) [a73]
──a7─│───┐ ┌────────────
┌─────┐│ │[a74]=[-75mv]
│n*a70│──>[a71]┐ │
└─a700┘│[a70]─<┘ │
│ └>──┐ │
a700*10^4│ ├>┌──────┐
│ │ └────┐ │
│ ┌─┼─>────┼─┼─>
│ │ │ ┌────┘ │
│ │ └>└[a72]─┘
│ │ ┌<┼<┘│ │ [-75mv]
─│───────┘ │ │ │ └─[a3]────────
└─[a701]──┘ └<─│────na[u+].[0.1ms]
└─<─[a703]
│<-20nm-->│
│<──a710─>│

[a73]<->[a74]=-75mv
[k1]=4ms=open time
[k2]=[spike]
a74 ───┐ ┌───┐ ┌──── ┬
│<-k1->│ │ │ │<-[4pa]=[k2]
│ │ │ │ │
└──────┘ └──┘ ┴
a73 ──────────────────────

[spike]=na(u+)+k(u+)
=na(u+) ==>gaiguri muscle
=ca(u+) ==>ttagaibi,gabgagryu muscle
=na(u+)+Ca(u+) ==>cheogchu animal sim gn,changgogi golgyeog gn
=na(u+)+k(u+)+ca(u+) ==>yeonche animal
=na(u+) or k(u+) ==>motor neuron,ggolttugi axon


14nm │<-2nm->│
│ ┬┌──┐ ┌──┐ ┬
└─>││ │ │ │ │<-7nm
┌───││ │ │ │─┴──────┐
│ ││ │ │ │ │
├───││ └───────┘ │─┬──────┤
│ ││ │ │<─3nm │
│ ┴└────[a72]────┘ ┴─ │
│ │<---6.5nm--->│ │
│ [cytosol] │
└───────────────────────────┘

[a703]=[acetylcholinester gasubunhai].protein.=260kd
=25000sec^-1=40micro.s
[pr1]<<──rr1.=[inhibitor]
h3c─co─o─ch2─ch2─n(u+)─3─(ch3)3
│ └─<─┐
└─<───┐│
┌───ser.─oh
└a703───┘
[pr2]
h3c─co ho─ch2─ch2─n(u+)─3─(ch3)3
└─────┐─<<─┬┐
┌───ser.─o hoh
└a703───┘└─<─┘
[pr3]
h3c─cooh
┌───ser.─oh
└a703───┘
[pr.end]
---------------------
----[rr1].start----
[a703.inhibitor]
;stryer.1077
[physostigmine],[neostigmine]

--[physostigmine]-------------
pr1.
┌ch3
h3c─nh─co──o─c─┬ch─c───c───ch2
┌>┘ ┌>┘ │ 2 2┤ │ │
a703└─<┐│ ch┬ch─c─n─c─n─ch2
└=─ser─oh 2┘ ch3─┘ └h└ch3
pr2.
┌ch3
h3c─nh─co ho─c─┬ch─c───c───ch2
└┐ │ 2 2┤ │ │
a703 │ ch┬ch─c─n─c─n─ch2
└=─ser─o 2┘ ch3─┘ └h└ch3
pr3.[slow.reaktion]
h3c─nh─co hoh
└┐<<─┴┘│
a703 │ │
└=─ser─o──<──┘

pr4.
h3c─nh─cooh
a703
└=─ser─oh

[neostigmine].[slow.reaktion]
h3c─┐
h3c─n──co──o─c─┬ch─c─n(u+)
┌>┘ ┌>┘ │ 2 2┤ └3─[ch3]3
a703└─<┐│ ch┬ch─ch
└=─ser─oh 2┘

------[sehr.stabil].start-----
[tabun]
ch3──┐o─2┐
ch3──n───p────cn
h5c2o────┘
[sarin]
o─2┐
ch3─────p────f
ch3──ch─o┘
ch3──┘
[dipf]
ch3─┐ o─2┐
ch3─ch───p────f
ch3──ch─o┘
ch3──┘
[parathion]
s─2┐
h5c2o────p────o─c─┬ch─ch
h5c2o────┘ │ 2 2┤
ch┬ch─c─no2
2┘
[dipf]
pr1.
ch3─┐ o─2┐ ┌<<──oh──ser.─=enz.
ch3─ch───p────f │
ch3──ch─o┘ └<─┘
ch3──┘
pr2.[sehr.stabil]
ch3─┐ o─2┐ ┌─o──ser.─=enz.
ch3─ch───p─┘ hf
ch3──ch─o┘
ch3──┘
------[sehr.stabil].start-----

----[rr1].end----

[motor.neuron.cat]
na(u+)=150.mM=+60mv
k(u+) =(5.5).mM
cl(u-)=125.mM=-70mv
┌─[a1]────────────────
│ na(u+)=15.mM
│ k(u+) =150.mM=-90mv
│ cl(u-)=9.mM
│
└──────────────────────

b110=haisu b120=ggolttugi.blut
b130=axon b140=gaiguri.blut b150=muscle

b110 b120 b130 b140 b150 =[mM]
na(u+) 460 440 50 120 9.2
k(u+) 10 200 400 2.5 140
cl(u-) 540 560 40<>150 120 3<>4
ca(u2+) 10 10 0.4
mg(u2+) 53 54 10
(u-) 350

-----[!synapse].end-------

-----[!axon].start--------------
;stryer.1066
a5=[axon]=[chugsag]
[a500]=na(u+).weg [a501]=k(u+).weg

┌[a1]┐ [a502]
│ └───[a5]────────────────┐
│ [a501]=-60mv │
│ ┌──> ┌─<─ │
│ [a500]─=┬─┼─┐ ┌─┼─┬=[a501]│
│ ┌────│ │ │──│ │ │───────┘
└────┘ └─┼─┘ └─┼─┘
na(u+)─>──┘ │
k(u+)─<────<────┘
[a505]=[502]<->[a501]=-60mv
[k1]=4ms=open time
[k2]=[spike]
a501───┐ ┌───┐ ┌──── ┬
│<-k1->│ │ │ │<-[3pa]=[k2]
│ │ │ │ │
└──────┘ └──┘ ┴
a502──────────────────────

[a500] [a501] =realative.durchgehen
Li(u+) 0.93 <0.01
Na(u+) 1.00 <0.01
k(u+) 0.09 1.00
Rb(u+) <0.01 0.91
Cs(u+) <0.01 <0.08
nh4(u+) 0.16 0.13
nh3(u+)oh
0.94 <0.03
nh3(u+)nh2
0.59 <0.03
nh3(u+)ch3
<0.01 <0.02


--[a500]=na(u+).weg.start------
[a500]=[na weg].axon
[a500]=[270kd+39kd+37kd].mouse
=[270kd].baimjangeo
=[[alpa helix]*6]*4
not.[schwann cell].axon=(20.no).((micro.m)^2)^-1.a500
=200nm.abstand.
[schwann cell].axon-->[node of ranvier]
=(10000.no).((micro.m)^2)^-1.a500
=10nm.abstand.

Na(u+)=high.(u-).[small.r]─pro.

┌──[a500].side──────────────────────┐
├─────coo(u-)───coo(u-)────coo(u-)──┘
│ └....┐ └....┐ └....┐ └....┐
│<--li(u+) na(u+) nh3(u+) nh3(u+)
│<--h2o h2o └─oh └─nh2
│ └─..─┐ └─..─┐ └─..─┐ └─..─┐
├─────coo(u-)──coo(u-)────coo(u-)────┐
└────────────────────────────────────┘
┌──────┬────=not.durchgehen
k(u+) nh3(u+)
h2o └ch3

s1=[alpa helix],s2=[alpa helix](u+)
s3=hole

┌─[a500].oben───────┐
│ s1───s1 s1───s1 │
│ │ s2 ├─s1 │ s2 │ │
│ s1───s1 s1─┬─s1 │
│ ┌───┐ │ │
│ s1 │ s3│ s1 │
│ │ └───┘ │
│ s1─┴─s1 s1───s1 │
│ │ s2 │ s1┤ s2 │ │
│ s1───s1 s1───s1 │
└───────────────────┘

[inhibitor]
[tetrotoxin]=[bog eo]

o(u-)┐ h┐
o────c───coh
┌┼────┘ │
│└─ch─coh─c─────nh─┐
│ │ └h │ nh2(u+)
o──┼ch────ch──c─nh─┘
││ └oh
┌─c┘
oh└oh

[saxitoxin]=daihab=honghab

ch2─o─co─nh2
└─────┐
┌─nh──ch─ch──nh─┐
h2n(u+) │ nh2(u+)
└─n──────c───nh─┘
│ │ ┌oh
ch2 └─c─oh
└────────┘

--[a500]=na(u+).weg.end------
-----[!axon].end-------------

-----[!soma].start---------

---[filament&microtubules].start----
[microfilament]
a─┐..┌──┐..┌─
b.└──┘..└──┘.. 7nm.d. [actin].pro.
[intermediate filament]
┌─────────────┐
└─────────────┘ 10nm.d. several.pro.
[muscle thick filament]
┌───#──────#──┐
├─#─────#─────┤
└─────#─────#─┘ 15nm.d. [myosin].pro.
[microtubules]
┌─────────────┐
│ │
└─────────────┘ 25nm.d. [tubulin].pro.
---[filament&microtubules].end----

-----[!soma].end---------
!neuron.speed
--------[duiBBuridlsinGyeongseomyu]---
gun .d. speed
[micro.m] [m/sec] [suyong gi]

1a 12<->20 70<>120 gnyugbangchu
1b 12<->20 70<>120 himjul gigoan

2 6<->12 36<>75
3 2<->5 12<>30 (ondo,tong gag)
4 0.5<->2 1.5<>2 jayusin gyeong jongmal
---------[malchosinGyeongseomyu]----
gun .d. speed
[micro.m] [m/sec] [suyong gi]

a 1<->20 5<>120 jin,chog,ab,tong,ondo
b 1<->3 3<>15 naijang
c 0.5<->1.5 0.6<>2 naijang
---------[gaigurisinGyeongseomyu]----
gun .d. speed
[micro.m] [m/sec]

a 18.5 42
a 14.0 25
a 11.0 17
b 4.2
c 2.5 0.4<>0.5

-------[!jungchuSinGyeongGyeoi]----
--[hoiBaigjil].start---
[c100]=[hoidolgisepo]=[oligodendroglia]
[c101]=[seongsangGyosepo]=[astrocyte]
[c102]=[mosehyeolgoan]
[c103]=[misegyosepo]=[microglia]=move.cell
┌a1──┐
│ └──a5────┐
│ ┌──────┬─┘
└───┬┘ ┌*─┘
* ┌─┴──────┐
└┬*┤[c100] │
┌*┘ └──┬─────┘
┌a1┴─┐ └*┐
│ └──a5──┴─┐
│ ┌────────┘
└───┬┘
* ┌────────┐
└**┤[c101] ├─┐
└┬────┬──┘ │
┌─***┘ ┌**┘ ┌**┘
┌──┴──────┴────┴───┐
└──[c102]──────────┘
* ┌────────┐
└**┤[c103] ├─┐
└┬────┬──┘ │
┌─***┘ ┌**┘ ┌**┘

----[hoiBaigjil].end---

----[baigjil].start---

┌─────────[a5]───────────┐
└──┬──────────┬──────────┘
└┬─────[a2]┘
│ ┌────────┐
└─****┤[c100] │
└────┬───┘
┌─******─┘
┌─┴─────[a2]─┐
┌──┴────────────┴───────┐
└─┬─┬─────────[a5]──┬───┘
│ └*****─┐ ┌─***─┘
│ ┌─┴──┴───┐
└─*****┤[c101] ├─┐
└┬────┬──┘ │
┌─***┘ ┌**┘ ┌**┘
┌──┴──────┴────┴───┐
└──[c102]──────────┘
----[baigjil].end-----

---[!axonal transport].start---
[at10]=[anterograde]=[sunhaingseong]
[at11]=[retrograde]=[yeoghaingseong]

----[a10]----
[fast] 420mm/day -->[at15]=dangdanbaigjil,dangjijil
,hoahagjeondalmuljil
[slow] 1<->5mm/day -->[at22].20micro.m.long= actin,tublin,neurofilament
----[a11]----
150<->40mm/day -->[at20]=polyvesicles,lysosome,ngf,toxin

[at12]=[microtubules]=[misogoan]
[at16]=[at15]+n.[at17].active+n.[at18]
[at21]=[at20]+n.[at17]+n.[at18].active
[at23]=[at22]+n.[at19].active

┌─[a1]──┐
│ └───────[a5]───────────┐
│ ┌[at16]┐ ┌[at21]┐│
│ │ │--> <----│ ││
│ └┬┬┬┬┬┬┘ └┬┬┬┬┬┬┘│
│ ┌──────────[at12]──────────┐│
│ └─[-end]─────────────[+end]┘│
│ <--[at23]--> │
│ ┌──────────────────────┘
└───────┘

----[motor.protein]----
[at17]=[kinesin]=atpase=360kd=+end
[at18]=[dynein]=atpase=1200kd=-end
[at19]=[dynamin]=gtpase=100kd=+end,-end

[at17]=[myosin].gleich
at17,at18 =modn yuhiagsepoE jonjai
---[!axonal transport].end---

---[!neuron__].end---

-----[!muscle__].start-----

[!contrac.]
[!spr]=[sarcoplasmic reticulum]
[z1]=z.line [h1]=h zone [i1]=i band
[a1]=a band=1500nm
[!a2]=[!myosin filament]=thick.filament=1500nm.long.16nm.d.
[a3]=f actin filament=[!thin filament]=1000nm.long.7nm.d.
│<------[2300nm]------>│
┌───a1────┐
─i1──┐┌─h1──┐ ┌─i1──┐
──┬─── ─────┬─── ────┬───
│ ┌───┬─a2──┐ │ ┌───┬───┐ │
│ └───┼─────┘ │ └───┼───┘ │
──┼─── │ ─a3──┼─── │ ────┼───
[z1] ┌───┼─────┐ │ ┌───┼───┐ │
│ └───┴─────┘ z1 └───┴───┘ z1
──┴─── ─────┴─── ────┴───

117117555755577711711711171177117111
->1=white 7=black 5=brown

---------------------------------
---------------------------------
[a3]=f actin filament=[!thin filament]
[a301]=[actin]=[g actin]=42kd=5.5nm.d.kreis=atpase
=[0.6].M.ki.chuchul
[a310]=[a301]*7=38.5nm.long=9nm.d.
[a311]=[a310]+[a310]=38.5nm.long.[2.helix]=[f actin]

[a302]=[tropomyosin]=68kd=40nm.long.[2.alpa.helix]

[a320]=[troponin]=[tni]+[tnc]+[tnt]
[tni]=24kd=[a311].vervindung
[tnc]=18kd=ca(u2+).vervindung
[tnt]=38kd=[a302].vervindung

[a3]=[ [a311]+[a320]+[a302]=38.5nm]*n

┌───[a311]────────────────┐┌──────────┐
│ ││ │
└─────────────────────────┘└──────────┘
┌─[tni]─┐─**─┘
├─[tnc]─┤
├─[tnt]─┤─**─┬─*****─┐
└─[a320]┘ │ │
──┬───[a302]──────────────┐ ───┬────────┐
───└───────────────────────┴─── └────────┘

-------[!myosin filament].start----
[!a2]=myosin filament=thick.filament=540kd or 460kd
=[0.6.M.kCl+0.01.M.ppi+1mM.MgCl2]=[6.5.ph].chuchul
=[hasselbachschneider.aq]=[6.4.ph].chuchul

[!a210]=100kd=4nm*11nm
[a211]=20kd [a212]=20kd
[a213]=140nm.long.2nm.d.[2.alpa.helix]
[m1]=hmm s-1=21nm [m5]=hinge=trypsin.cut
[m2]=hmm s-2=60nm =110kd [m6]=hinge=papain.cut
[!m3]=lmm =80nm =150kd.[2.alpa.helix]

┌──────[a200]─────────────┐
┌─=[m5] ┌─=[m6]
┌[m3]─┐┌─[m2]─┐┌──[m1]───┐

a211┌a210┐
a212│ │
c┌──[a213]──────┐****└────┘
c└──────────────┘****┌a210┐
a212│ │
a211└────┘

[a2]=[a200]*150<>360
[abstand]=ganGyeog [winkel]=gagdo
[a230]=bare zone=150nm
[a237]=14.3nm.abstand.120winkel.drehen
1jugi=360winkel=6*[a210]=42.9nm

┌─a230──┐
┌a210 ┌a210
┌│──────│───────┐ ┌─[a2]──┐
│└a200*┐└a200*┐ └───────┘ │
│┌a200*┘┌a200*┘ ┌───────┐ │
└│──────│───────┘ └───────┘
└a210 └a210
└─────────┴───=[a237]

--[!a210]=100kd=4nm*11nm.start------
am1=gly.glu.ser.gly.ala.gly.lys.thr

am1=─┬─***atp
┌──│────────[a210]┐
│n┌┴─────┐**┌────┐│
│ └─27kd─┘ │50kd││
┌─[a213]──┐**c┌─22kd─┐ │ ││
└─────────┘┌──└──────┘**└────┘│
a211***s─┤└───────│────│────┘
a212***s─┘ └─**─┴**──[a301]=actin

--[!a210]=100kd=4nm*11nm.end------

--[!m3]=lmm=80nm =150kd.start--
[m3]=lmm=80nm.long=150kd.1300.amino
[m301]=80nm.long.1nm.d.=alpa.helix
[m302]=80nm.long.1nm.d.=alpa.helix
[m3]=80nm.long.2nm.d.
=[m301+m302].[2.alpa.helix]

┌─────────[m3].d.────────────────┐
┌───[m301].d.──┐ ┌───[m302].d.───┐

┌g1─┐ ┌>e1─>┐
│ │ │ │
c1─┼>>─┼──d1 a1─┼─>───┼b1
┌>─┼─>┘ │┌<─┘ rpt.┐│ └┼─>─┐
f1 │ └┼─┐ ┌>┼┘ │ f1
└<─┼─<┐ │ rpt. │ │ ┌<┼─<─┘
b1─┼─<<─┼─a1 d1┼──<──┼─c1
│ │ │ │
└e1<─┘ └<─g1<┘

a1=b1=c1=e1=f1=g1=amino.
[m301]=n[a1+b1+c1+e1+f1+g1].alpa.helix
a1=d1=sosuseong b1=c1=f1=jeonha seong

-------[!myosin filament].end----
------[!spr].start--------
[sarcoplasmic reticulum]=[sarkotubulaire system]
=[gnsopoche]=[sr]=[80%.phospholipid+20%.cholestrol].membrane
=10^-3M.Ca(u2+).cytosol
[sr2]=ca(u2+).pump=atpase=100kd=2ca(u2+).move./1atp
[sr3]=phosphodiesterase[=pde]
[sr5]=ca(u2+).weg=[!ip3.receptor]
[sr6]=injijil=magjijil=[phosphatidylinositol]
[sr10]=tt=transverse tubule
┌───[a5] ────────┐
└───────────────┐│
┌──┘└──┐
┌─┬=sr10 sr10 =┬──┐ │- - - │ ──┬─=[a710]
│+ + + + + + + + + ++ └─[a7]─┘ │
└─┐+┌─────────────────┐ +┌─────────────┐ │
│+│- - - -70mv - - -│ +│ - - - - - - │ ──┘
│+│┌──┐ ┌──┐┌┬─┼─=sr3 │
│+││ └─sr──────┘ │││+├─┬=sr6
│+││ ┌─>──────┐ │└┘+├─┘
│+││ ┌┼┐ ┌┼┐ ││ +│
└─┘└──│││──────│││─┘└──┘
└┼┴=sr2 └┼┴=sr5
│ └─>
└─<──ca(u2+) < 1micro.M
┌───a1────────┐
┌─i1──┐┌─h1──────┐ ┌─i1──┐
│ │
│ │
z1 z1



---[sr2]=atpase.start------
pr1.
┌<─2(ca(u2+))
┌─────┐┌─<──atp
└─sr2─┘┘
pr2.
┌──2(ca(u2+))
┌─┴───┐┌────atp
└─sr2─┴┘ └─<─h2o
└───>2(ca(u2+))
pr3.
┌─────┐┌────pi adp
└─sr2─┴┘ └─<─Mg(u2+)
2(ca(u2+))

pr4.
┌─────┐ pi
└─sr2─┘
2(ca(u2+))

pr5.
=myoplasm.side
┌─────┐
└─sr2─┘
2(ca(u2+))=cytosol.side
---[sr2]=atpase.end------

---[!ip3.receptor].start----
j10-->
[sr3]=phosphodiesterase[=pde]
dg=diacylglycerol ip3=[1,4,5 triphosphate]
pi──┐ ┌─pi
┌┴──┴─┐
│[ip3]├─pi─[dg]
└─────┘ └────<<──h2o

11-->
pi──┐ ┌─pi
┌┴──┴─┐
│[ip3]├─pi ho─[dg]
└─────┘
12-->
[sr5]=ca(u2+).weg=[!ip3.receptor]
┌──<<──[ip3]
┌───┴─┐
│[sr5]│
└─────┘
13-->
┌─<<─n[ca(u2+)]
│ ┌──[ip3]
┌─│────┴─┐
│ │ [sr5]├=weg.open
└─│──────┘
└──>>
---[!ip3.receptor].end----




------[!spr].end--------

---------[!contrac.].start--------
[a301]=[actin] [a200]=myosin

j20-->
┌─────[a3]────┐ ┐
│ [a301] │ ├=7nm.d.
└──│──────────┘ ─┐┘
└─a210<<───atp ├=13nm.abstand
┌──│──────────┐─┘┐ ;stryer.973
│ └─a200 │ ├=15nm.d.
└───[a2]──────┘ ┘

j21-->
┌─────[a3]────┐
│ [a301] │
└─────────────┘
a210───atp<<──h2o
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j22-->
┌─────[a3]────┐
│ [a301] │
└─────────────┘
a210───adp+pi
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j22_100-->

┌─<<─Ca(u2+)
┌─────[a3]─│──┐
│ [a301] [tnc]│
└─────────────┘
a210───adp+pi
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j22_110-->
[a302]=[tropomyosin]=68kd=40nm.long.[2.alpa.helix]

┌──Ca(u2+)
┌─────[a3]─│──────────────┐
│ [a301] [tnc] [a302].move│
└──│──────────────────────┘
└<<─a210───adp+pi
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j23-->
v=weak.bond
┌─────[a3]────┐
│ [a301] │ ┌───>>pi
└──│──────────┘ │
v=┴───a210───adp+pi
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j24-->
v=mid.bond
┌─────[a3]────┐
│ [a301] │ --->[7.5nm].move
└──│──────────┘┌──>>adp.20micro.s
v=┴───a210───adp pi
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘

j25-->
v=stark.bond
┌─────[a3]────┐=───┐
│ [a301] │ [7.5nm].move
└──│──────────┘ adp
v=┴───a210
┌──│──────────┐
│ └─a200 │
└───[a2]──────┘







uuii.txt
[end]----------------------------------------------